Urinary disorders have become common in the current age. In fact, 30% of men and 40% of women in the US suffer from an overactive bladder (source). It results in frequent urination urges, reduced bladder capacity, and urgency to pass urine. While there are many other urology treatments, Mirabegron is widely used because of its fewer side effects. In this blog, we will discuss the demand for Mirabegron API, its uses, dosage, and side effects.
What is Mirabegron API?
Mirabegron API is used to create Mirabegron drugs for the treatment of urological conditions such as overactive bladder. It is an FDA-approved drug used to treat people who suffer from frequent urination, incontinence, and reduced bladder capacity. It is often used alone or with other urology drugs like Solifenacin.
Mirabegron, also known by its brand name Myrbetriq, is a beta-3 adrenergic agonist used to relax the smooth muscles in the urinary bladder. The chemical formula of Mirabegron is C21H24N4O2S. The half-life of the drug is 50 hours for treating an overactive bladder. However, the half-life of the granule Mirabegron formulation for pediatric patients with neurogenic detrusor overactivity is 26-31 hours.
Why is Mirabegron in demand in pharma?
Unlike the other overactive bladder treatment drugs, the Mirabegron targets the beta-3 adrenergic receptors and lacks antimuscarinic activity. It reduces the side effects compared to other treatments, making it popular in the pharma world. Therefore, the Mirabegron API market stood at $1.2 billion in 2024, and it is expected to grow at 9.2% CAGR between 2026-2033, reaching $2.5 billion in 2033 (source). The effectiveness of the drug, its availability, and the comparatively low side effects contribute to the popularity of Mirabegron for urology treatment.
What is the mechanism of Mirabegron API?
Mirabegron API gained popularity as one of the best bladder treatment APIs because of its mechanism of targeting the beta-3 adrenergic receptors. The API stimulates the receptors, causing the smooth muscles of the urinary bladder to relax. It reduces the frequent urge to urinate and helps the urinary bladder hold more urine.
What is the use of Mirabegron?
The Mirabegron API is used to create drugs for urinary disorders and is used for treating the following two conditions. Overactive bladder (OAB) Overactive Bladder (OAB) is a condition characterized by the loss of control of the urinary bladder. It results in frequent urination, the urge to urinate even when the bladder is not full, or incontinence. It has become a common condition in many adults. Mirabegron is used as the first treatment for OAB by 67% of healthcare professionals instead of the anticholinergic drugs(source). If patients don’t find effective results, doctors often use Mirabegron and Solifenacin together for better results.
Neurogenic Detrusor Overactivity (NDO)
Neurogenic Detrusor Overactivity is when the bladder becomes overactive due to neurological conditions, such as Multiple Sclerosis (MS) and spinal injury. Like the OAB, the patients with NDO also experience frequent urges to urinate, incontinence, and lack of bladder control. Mirabegron helps reduce contractions and regulates urinary bladder activities. As per a study, 73% of patients with NDO saw a positive impact of Mirabegron, and the number of patients decreased from 60.3% to 38.1% (source).
How to consume Mirabegron for urology treatment?
There are two pharmaceutical forms of Mirabegron used for treating urology conditions, the OAB and NDO, as mentioned below.
- Oral tablet: The tablets are allowed whole with water and not crushed or chewed. An adult patient can consume it before or after food intake as per the doctor’s guidance. However, for kids, it’s better to be consumed after food intake.
- Oral liquid (suspension): The Mirabegron granules are used to create an oral suspension for urology treatment. The solution can be used for 28 days only. Store the bottle away from sunlight and shake it well before use to ensure uniform suspension.
What are the side effects of Mirabegron?
Mirabegron is known for its minimal side effects, but there are still some side effects that you must know. The following are a few common side effects some patients experience after consuming Mirabegron.
- Hypertension (high blood pressure)
- Infection in the nose and throat
- Kidney infection
- Constipation
- Headache
- Angioedema allergic reaction
Precautions for Mirabegron treatment If you have a medical condition, you must discuss it with your doctor before starting the Mirabegron treatment. A rise in blood pressure is a common side effect of the drug. Therefore, heart patients are advised to avoid this medicine.
The following is the list of people who should use Mirabegron with caution for urology treatment:
- Heart patients
- Kidney problem patients
- Liver problem patients
If you experience urine blockage, immediately stop taking Mirabegron and contact your healthcare provider. Chemox Pharma: Trusted Mirabegron API supplier Chemox Pharma is a trusted manufacturer of Mirabegron Intermediates and APIs for urology treatment drugs. Our state-of-the-art manufacturingunit at Dahej is equipped with high-end technology and a team of skilled scientists and lab technicians to create effective and safe APIs and intermediates.
We can help you create the Mirabegron API in your desired IH, BP, USP, IP, and EP standards. We can help you create custom packaging that fits your needs. Contact us now with your queries.
Conclusion
Mirabegron API is used in drugs for urinary disorders. It is the primary medicine used for treating Overactive Bladder and Neurogenic Detrusor Overactivity. In both conditions, the patient loses control over the urinary bladder and experiences frequent urination before the bladder is full, and many experience incontinence.
Mirabegron stimulates the beta-3 adrenergic receptors that relax the smooth muscles of the bladder and help the patient gain control. The Mirabegron APIs have comparatively fewer side effects than other urology treatments, leading to greater demand in the market.
FAQ
How long does the effect of Mirabegron last?
The effect of the Mirabegron whether it is tablet or liquid lasts about 24 hours. For consistent results, take the medicine once every 24 hours without missing a dosage. It takes around 4-8 weeks to see results.
What’s the difference between Solifenacin and Mirabegron?
Both Solifenacin and Mirabegron are commonly used in treating OAB and NDO. While both are effective, they have two distinct mechanisms. Solifenacin is an anticholinergic agent that blocks the nerve signals that are responsible for bladder muscle contractions. On the other hand, Mirabegron stimulates the beta-3 adrenergic receptors that relax the bladder muscles, leading to better control over the bladder.
What are the benefits of using the Mirabegron API?
The Mirabegron API helps relax the smooth muscles of the urinary bladder in patients with overactive bladder and Neurogenic Detrusor Overactivity (NDO). The Mirabegron drug is known for its fewer side effects compared to other medications used in urological treatment.
