Bacterial infections have become resistant to many traditional treatments. Therefore, doctors use Tigecycline under hospital supervision in many severe bacterial infections. Tigecycline API is essential for creating the Tigecycline powder for intravenous injections. So, let’s understand how the Tigecycline API works, its antibiotic uses, and the side effects.
What is the Tigecycline API?
Tigecycline is a bacterial infection treatment API from the tetracycline antibiotics class. It is designed to combat bacteria resistant to traditional medicines and in critical conditions. Tigecycline API is an active ingredient commonly used in the formulation of Tigecycline, also called Tygacil.
Tigecycline API has a half-life of 27-43 hours, making it effective for infection treatment in critical conditions. Its CAS number is 220620-09-7, and the molecular formula is C29H39N5O8.
Tigecycline should only be prescribed under the supervision of a healthcare professional. It treats community-acquired bacterial pneumonia, skin infections, and abdominal infections.
How does Tigecycline API work?
Tigecycline inhibits the bacterial protein assembly essential for bacterial growth and replication. It attaches to the 30S ribosomal subunit and blocks aminoacyl-tRNA molecules.
Research has found that the prolonged post-antibiotic effect of Tigecycline is one of the most critical factors that make it effective against many antibiotic-resistant Gram-positive and Gram-negative pathogens. It is widely used against carbapenem-resistant Enterobacteriaceae, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae, and penicillin-resistant Streptococcus pneumoniae. (source)
What are the Tigecycline antibiotic uses?
Tigecycline API is used to create Tygacil, used by doctors to treat resistant bacterial infections. The following are a few common uses of Tigecycline antibiotics.
Skin and Skin-structure infection (SSSI)
Skin and skin-structure infection is a growing concern affecting skin health. The Gram-positive, Gram-negative, and anaerobic bacteria infect the deeper tissues of the skin. These bacteria, especially the S. aureus and Streptococcus, are resistant to traditional antibiotics. If not treated well, SSSI can be life-threatening. Therefore, Tigecycline has been used to tackle the SSSIs.
Complicated intra-abdominal infections (cIAI)
Intra-abdominal infections (IAI) have become a common problem in adults. However, the complicated IAI is a severe stage where the abdominal infection spreads from the infected organ. Patients with complicated intra-abdominal infection might have peritonitis, diverticulitis, cholecystitis, cholangitis, and pancreatitis. Critical care is essential to treat such abdominal infections. Tigecycline antibiotic is used in severe cases for better and lasting results.
Community-acquired bacterial pneumonia (CABP)
Pneumonia can be acquired in the hospital or in the community. Community-acquired bacterial pneumonia occurs when the bacteria enter your body in a non-hospital setting. Tigecycline is used when the CABP is severe or is resistant to other antibiotics.
The doctor may use Tygacil when the conventional antibiotics are not performing well. It comes in powdered form that must be diluted in a solvent for intravenous treatment. The dosage must be discussed with an authorized healthcare professional.
What are the side effects of Tigecycline API?
Depending on the patient’s health and allergies, Tigecycline might have some side effects. Patients must share their medical history and current treatments with the doctor before starting Tigecycline antibiotic treatment to avoid severe side effects.
A few common side effects one may experience during Tigecycline treatment are nausea, vomiting, diarrhea, stomach pain, and headache. If you frequently experience these symptoms, please get in touch with your healthcare provider for further diagnosis.
Tigecycline treatment also has severe side effects such as liver damage, pancreatic inflammation, teeth discoloration, bone growth problems, increased intracranial pressure, or other severe allergic reactions. You should immediately contact your doctor when experiencing any of the symptoms of severe side effects.
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Conclusion
While bacterial infections are becoming more resistant, Tigecycline API is used to create Tygacil against multidrug-resistant (MDR) bacteria. Tigecycline inhibits the protein formation necessary for bacterial growth and replication. It has been used in severe cases of Skin and Skin-Structure Infections, Complicated Intra-Abdominal Infections, and Community-Acquired Bacterial Pneumonia. It is used as an intravenous drug under the prescription of an authorized healthcare professional. Look for side effects like vomiting, nausea, diarrhea, headache, and stomach pain. Get high-quality Tigecycline API tailored to your requirements from Chemox Pharma.
FAQ
What is the dosage of Tigecycline?
Tigecycline is injected slowly into the bloodstream through the veins. The dosage depends on the severity of the patient’s condition and other underlying medical complications. The doctor gives small dosages over a specific period, such as 12 hours. Consult with a healthcare professional for more information.
What are the benefits of using Tigecycline API?
The Tigecycline API is beneficial in treating multidrug-resistant (MDR) bacteria causing skin, abdominal, and lung infections. Its prolonged antibiotic effect with a long half-life makes it one of the preferred medications for treating severe infections.
What precautions should I take before using Tigecycline API?
Inform your doctor about any existing medical conditions, such as diabetes, allergies, liver conditions, or more, before starting Tigecycline treatment. Tigecycline is generally avoided for pregnant women and children. Ask your healthcare provider beforehand if the drug is safe for you or not.
