Olmesartan Intermediate OLMI-1 (CAS 144689-93-0): Specifications & Sourcing Guide

OLMI-1 sits right at the core of Olmesartan Medoxomil’s molecular structure — it’s the imidazole intermediate that everything else in the synthesis route gets built onto. If your process depends on this intermediate, its purity and consistency aren’t just one input among many; they set the quality ceiling for every downstream step that follows. Understanding what Olmesartan Intermediate OLMI-1 actually is, and what to verify before you source it, matters more here than for almost any other intermediate in the chain.

This guide covers OLMI-1’s specifications, its role in Olmesartan Medoxomil synthesis, and what to look for in a manufacturer before you place an order.

What Is Olmesartan Intermediate OLMI-1?

OLMI-1 is the chemical intermediate Ethyl 4-(2-hydroxy-2-propyl)-2-propyl-imidazole-5-carboxylate, registered under CAS number 144689-93-0. It has the molecular formula C12H20N2O3 and a molecular weight of approximately 240.30 g/mol.

Structurally, OLMI-1 is a substituted imidazole carboxylate — the core heterocyclic ring system that forms the structural backbone of Olmesartan Medoxomil. The imidazole ring, along with its propyl and hydroxy-isopropyl substituents, remains intact through the rest of the synthesis, meaning any structural or purity issue introduced at this stage carries through to the finished API.

Where OLMI-1 Fits in Olmesartan Medoxomil Synthesis

OLMI-1 provides the imidazole core onto which the biphenyl-tetrazole moiety (introduced via an intermediate like TTBB) is coupled, before the medoxomil ester group is finally installed using DMDO-CL. In practical terms, OLMI-1 is the foundation intermediate — the synthesis route builds outward from this molecule rather than modifying it after the fact.

Because it enters the process this early, OLMI-1’s purity has a compounding effect: impurities present at this stage don’t just remain in the final product, they can also interfere with the coupling and esterification reactions that follow, reducing yield at every subsequent step rather than just the final one.

Key Specifications to Verify

Before sourcing OLMI-1, buyers should confirm the following from any supplier:

• Assay/purity — request the manufacturer’s HPLC assay specification along with a batch-specific Certificate of Analysis.
• Related substances/impurity profile — given OLMI-1’s foundational role, tighter impurity control here has an outsized effect on downstream reaction yield.
• Residual solvents — confirm compliance with ICH Q3C guidelines for the manufacturing process used.
• Melting point and physical characteristics — useful as a quick identity and purity cross-check alongside the CoA.
• Batch-to-batch consistency data — particularly important for buyers running continuous production rather than one-off batches.

Why Sourcing OLMI-1 From the Manufacturer Matters

Given how early OLMI-1 enters the synthesis route, sourcing it from a trader rather than the actual manufacturer carries more downstream risk than it might for a later-stage intermediate. Buying direct from the manufacturer gives you:

• Consistent purity from a single controlled process, rather than material that may shift in quality depending on what a trader could source.
• Direct access to batch-specific documentation and technical support.
• A direct line to the production team for troubleshooting if a yield issue traces back to raw material quality.
• More predictable, production-linked pricing instead of trader-driven price volatility.

OLMI-1 at Chemox Pharma

Chemox Pharma manufactures OLMI-1 (CAS 144689-93-0) at our WHO-GMP certified facility in Dahej, Gujarat, as part of a backward-integrated Olmesartan intermediate portfolio that also includes DMDO-CL and TTBB. This gives Olmesartan Medoxomil manufacturers the option to source the full synthesis-chain intermediate set from a single, accountable factory rather than coordinating supply across multiple traders.

Questions to Ask Before You Order

• Can you confirm your HPLC assay specification and provide a batch-specific CoA?
• What is your related-substances/impurity profile for this batch?
• Are you the manufacturer, or are you reselling material sourced elsewhere?
• Can you supply consistent batch-to-batch quality for ongoing production requirements?

Request a Quote for OLMI-1

If you’re sourcing OLMI-1 for Olmesartan Medoxomil synthesis and want to work directly with the manufacturer, get in touch with Chemox Pharma for a quote and sample evaluation.

FAQs

Q: What is OLMI-1 used for? OLMI-1 (CAS 144689-93-0) provides the core imidazole ring structure used in the synthesis of Olmesartan Medoxomil, forming the foundation onto which later synthesis steps are built.

Q: What is OLMI-1’s molecular formula and weight? OLMI-1 has the molecular formula C12H20N2O3 and a molecular weight of approximately 240.30 g/mol.

Q: Why does OLMI-1’s purity matter so much for Olmesartan Medoxomil manufacturers? Because it enters the synthesis route at an early stage, impurities in OLMI-1 can affect yield at every subsequent reaction step, not just the final product — making its specification especially important to verify.

Q: Does Chemox Pharma manufacture OLMI-1 in-house? Yes. Chemox Pharma manufactures OLMI-1 at its WHO-GMP certified facility in Dahej, Gujarat, alongside related Olmesartan intermediates DMDO-CL and TTBB.