Olmesartan Intermediate DMDO-CL (CAS 80841-78-7): Specifications & Sourcing Guide

If you manufacture Olmesartan Medoxomil, DMDO-CL is one of the intermediates your synthesis route depends on directly  it’s the reagent responsible for building the medoxomil ester group that gives Olmesartan Medoxomil its prodrug character. Getting this intermediate’s purity and specification right has a direct, measurable effect on your esterification yield, which makes supplier selection here more consequential than it might first appear.

This guide covers what Olmesartan Intermediate DMDO-CL actually is, its key specifications, where it fits in the synthesis route, and what to look for in a manufacturer before you order.

What Is DMDO-CL?

DMDO-CL is the chemical intermediate 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one, registered under CAS number 80841-78-7. It has the molecular formula C5H7ClO3 and a molecular weight of approximately 150.56 g/mol.

Structurally, DMDO-CL is a chloromethyl-substituted dioxolone the same reactive scaffold behind the “medoxomil” prodrug ester group used in Olmesartan Medoxomil. The chloromethyl group makes it the reactive alkylating agent used to attach this ester functionality onto the core Olmesartan structure during synthesis.

Where DMDO-CL Fits in Olmesartan Medoxomil Synthesis

Olmesartan Medoxomil is a prodrug the medoxomil ester group is what allows the molecule to be orally absorbed and then hydrolyzed to the active Olmesartan acid in the body. DMDO-CL is the reagent used to install that ester group late in the synthesis route, alkylating the carboxylic acid on the core imidazole-biphenyl-tetrazole structure (built up earlier using intermediates like OLMI-1 and TTBB) to form the final medoxomil ester.

Because this is a late-stage synthesis step, DMDO-CL’s purity has an outsized effect on final API yield and impurity profile — any related-substance contamination in this reagent tends to carry through into the finished Olmesartan Medoxomil batch rather than getting purged in an earlier step.

Key Specifications to Verify

When sourcing DMDO-CL, buyers should confirm the following from any supplier:

• Assay/purity — confirm the manufacturer’s HPLC assay specification and request a batch-specific Certificate of Analysis, not a generic template.
• Related substances/impurity profile — given DMDO-CL’s late-stage role in synthesis, tighter impurity control here directly reduces downstream purification burden.
• Residual solvents — confirm compliance with ICH Q3C guidelines for the manufacturing process used.
• Physical form and storage stability — chloromethyl dioxolone compounds can be moisture- and temperature-sensitive; confirm the manufacturer’s recommended storage conditions and shelf-life data.
• Packaging suitable for the compound’s stability profile — appropriate moisture protection matters for maintaining spec during transit and storage.

Why Sourcing DMDO-CL From the Manufacturer Matters

DMDO-CL moves through B2B chemical marketplaces alongside many other fine chemical intermediates, and not every listed “supplier” is the actual producer. Buying from the manufacturer directly  rather than a trader gives you:

• Batch-consistent purity, since the material comes from a single controlled process rather than whatever a trader could source that month.
• Direct access to technical documentation and batch-specific CoAs.
• A direct line to the production team if a purity or yield issue needs troubleshooting.
• More stable pricing, tied to actual production economics rather than a trader’s fluctuating sourcing costs.

Olmesartan Intermediate DMDO-CL at Chemox Pharma

Chemox Pharma manufactures DMDO-CL (CAS 80841-78-7) at our WHO-GMP certified facility in Dahej, Gujarat, as part of a backward-integrated Olmesartan intermediate portfolio that also includes OLMI-1 and TTBB. This means Olmesartan Medoxomil manufacturers can source multiple synthesis-chain intermediates from a single, accountable factory rather than coordinating supply across several different traders.

Questions to Ask Before You Order

• Can you confirm your HPLC assay specification and provide a batch-specific CoA?
• What is your related-substances/impurity profile for this batch?
• Are you the manufacturer, or are you reselling material sourced elsewhere?
• What are your recommended storage conditions and shelf-life for this material?

Request a Quote for DMDO-CL

If you’re sourcing DMDO-CL for Olmesartan Medoxomil synthesis and want to work directly with the manufacturer, get in touch with Chemox Pharma for a quote and sample evaluation.

FAQs

Q: What is DMDO-CL used for? DMDO-CL (CAS 80841-78-7) is used as the alkylating reagent that installs the medoxomil ester group during Olmesartan Medoxomil synthesis, giving the API its prodrug character.

Q: What is DMDO-CL’s molecular formula and weight? DMDO-CL has the molecular formula C5H7ClO3 and a molecular weight of approximately 150.56 g/mol.

Q: Why does DMDO-CL’s purity matter so much for Olmesartan Medoxomil manufacturers? Because it’s used late in the synthesis route, impurities in DMDO-CL tend to carry through into the finished API rather than being purged in an earlier purification step, making its specification directly relevant to final yield and impurity profile.

Q: Does Chemox Pharma manufacture DMDO-CL in-house? Yes. Chemox Pharma manufactures DMDO-CL at its WHO-GMP certified facility in Dahej, Gujarat, alongside related Olmesartan intermediates OLMI-1 and TTBB.