You might know that Sildenafil Citrate API is widely used to treat erectile dysfunction. But did you know that it’s also used to treat PAH and Raynaud’s syndrome? Therefore, the demand for Sildenafil Citrate API has increased. We will discuss Sildenafil Citrate’s function, uses, dosage, and side effects.
What is Sildenafil Citrate?
Sildenafil Citrate is a well-known phosphodiesterase type 5 (PDE5) inhibitor that increases blood flow by relaxing the muscles. Therefore, it has been used to treat erectile dysfunction. Sildenafil Citrate API is used to create drugs for the treatment of ED and certain cardiovascular diseases.
The CAS number of Sildenafil Citrate is 171599-83-0, and its formula is C22H30N6O4S. Sildenafil Citrate has a half-life of 4 – 5 hours. Popular brand names include Viagra and Revatio (source).
How does Sildenafil Citrate work?
The PDE5 enzyme breaks down cGMP (cyclic guanosine monophosphate), which is responsible for smooth muscle relaxation. This breakdown leads to reduced blood flow and various health concerns. Sildenafil inhibits the PDE5 enzyme, resulting in muscle relaxation and improved blood circulation. Therefore, it is primarily used to treat circulatory diseases like ED and PAH. Studies have found that it effectively improves endothelial function, leading to better cardiovascular health and reduced lower urinary tract symptoms (source).
What are the uses of Sildenafil Citrate in pharma?
Sildenafil use in the pharma industry isn’t limited to treating ED. The following are a few uses of Sildenafil Citrate API.
Erectile Dysfunction (ED)
ED is common as men get older. By the age of 40, 40% of men suffer from some form of ED, and this number becomes 70% for men aged 70 (source). Sildenafil is one of the most common ED treatment drugs used by medical professionals , so men can maintain an erection for sexual activity. It is mainly known by its brand name, Viagra for ED treatment. A healthcare professional can help patients determine the best dosage based on their history.
Pulmonary Arterial Hypertension (PAH)
Pulmonary Arterial Hypertension indicates high blood pressure in the lungs, which might lead to heart failure. Therefore, Sildenafil relaxes the arterial muscles and reduces the blood pressure in the lungs. According to research, Sildenafil can also improve the exercise strength of people with PAH or heart conditions (source). A doctor’s consultation and health check-up are essential to include Sildenafil Citrate in one’s treatment plan.
Raynaud’s Disease
When exposed to cold temperatures or stress, a person suffering from Raynaud’s Disease experiences numbness and coldness in the fingers, toes and other extremities. It is also known as Raynaud’s phenomenon or syndrome. The narrowing of blood vessels has been one of the major causes of Raynaud’s syndrome. In recent studies, Sildenafil has effectively treated Raynaud’s phenomenon (source).
How can one consume Sildenafil Citrate?
Many types of drug forms are created using Sildenafil APIs. The following are a few of these types made by the pharmaceutical companies:
- Tablets: Sildenafil comes in tablet form for easy consumption and storage.
- Chewable tablets: Sildenafil is available in chewable tablet form to make it easy to consume.
- Jelly: Sildenafil jelly is available in various flavours, making it easy to carry.
- Liquid: A pharmacist will help you create an oral suspension for Sildenafil that you can store up to 60 days (source).
- Injections: In rare cases, Sildenafil is used as an intravenous solution to treat PAH.
What are the side effects of Sildenafil Citrate?
While Sildenafil Citrate is generally considered safe, there are a few side effects one should look out for. Common side effects are headache, body flushing, dizziness, and nasal congestion. Severe side effects are allergic reactions, painful erections, vision or hearing disturbance and low blood pressure. You must consult a healthcare professional before starting a Sildenafil Citrate treatment.
Why choose Chemox Pharma as your Sildenafil API manufacturer?
Chemox Pharma is a WHO-GMP-approved Sildenafil API manufacturer in India. We produce high-quality Sildenafil Citrate API for the development of effective drugs used in treating ED, PAH, and Raynaud’s Syndrome. Our bulk sildenafil API can be customized to meet your desired purity standard. Depending on your requirements, we can comply IP/BP/USP standards. Contact us today for any queries regarding Sildenafil API supply.
Conclusion
Sildenafil Citrate API is a PDE5 inhibitor commonly used in ED treatment. However, various studies and research have also found it effective in treating Pulmonary Arterial Hypertension (PAH) and Raynaud’s Disease. It can be administered as a standard tablet, jelly, chewable tablets, suspension liquid, or through injections. Sildenafil is available only with a doctor’s prescription. Chemox Pharma is a reliable Sildenafil API manufacturer known for our high-quality standards and timely delivery. Connect with us for any queries!
FAQ
How to check the quality of Sildenafil Citrate API?
To ensure the quality of the Sildenafil Citrate API, you must choose a manufacturer who complies with the WHO-GMP guidelines and can assist in creating products that meet IP/BP/USP standards. Review the API’s DMF, purity, particle sizes, and residues levels before selecting the supplier. Chemox Pharma is one of the most trusted Sildenafil Citrate suppliers with state-of-the-art manufacturing and R&D facilities. Contact us today to visit our site or inquire about an order.
What’s the difference between Sildenafil and Tadalafil?
Sildenafil and Tadalafil are well-known PDE5 inhibitors and are commonly used to treat erectile dysfunction (ED). Sildenafil lasts about 4 to 6 hours, whereas Tadalafil is known to be effective for up to 36 hours. Sildenafil is used to treat PAH and Raynaud’s Syndrome. Tadalafil is also used to treat BPH and PAH. You should speak with a physician to determine which is more effective for you.
Is Sildenafil suitable for long-term use?
Sildenafil is used for the long-term treatment of ED. However, you must consult a healthcare professional before continuing its use over the long term. Patients with existing medical conditions, especially regarding cardiovascular health, should proceed with Sildenafil Citrate treatment with caution. Drug manufacturers should conduct long-term stability tests to ensure the drug maintains a long shelf life and higher efficacy.
What are the dosage forms for Sildenafil?
The dosage of Sildenafil Citrate depends on the patient’s health condition and therapeutic needs. The typical dosage pattern for Sildenafil treatment is 25mg, 50mg or 100mg. You must consult a physician to determine the optimal dose for your condition and health status. Sildenafil is available in chewable tablets, suspension liquid, jelly, and injections.
