Sildenafil Citrate [Cas No. 171599-83-0] is a very powerful and selective PDE5 inhibitor which is mainly used to treat erectile dysfunction and pulmonary arterial hypertension [PAH]. Sildenafil Citrate has rapid onset of action, high safety and high efficacy which makes it a key component for oral formulations. It enhances the natural effect of nitric oxide [NO] by inhibiting cGMP specific phosphodiesterase type 5 [PDE5], an enzyme which is responsible for breaking cGMP. cGMP is a molecule which helps to smoothen the muscle relaxation and increases blood flow, thus by increasing cGMP level Sildenafil Citrate improve vascular relaxation and support good blood flow to the body tissues.
Chemox Pharma is a trusted manufacturer and is leading company in supplying Sildenafil Citrate. Chemox Pharma delivers high-quality APIs with strict quality assurance and supports all global regulatory documents such as WHO-GMP, FDA, DCGI. Chemox Pharma also house a well-equipped R&D Centre, focused on process development, quality improvement, and cost optimization—empowering us to meet the evolving needs of the global pharmaceutical industry.
| Sr. No. | Description | Application |
|---|---|---|
| 1 | PDE5 inhibitor API | Erectile dysfunction formulations |
| 2 | Urology therapeutic drug substance | Pulmonary arterial hypertension therapy |
| 3 | Vasodilator pharmaceutical ingredient | Male sexual health drugs |
| 4 | Smooth muscle relaxant API | Vascular relaxation therapy |
| 5 | Urogenital therapeutic API | Urology combination formulations |
Sildenafil Citrate is widely used by pharmaceutical manufacturers in urology and cardiovascular formulations for erectile dysfunction and pulmonary hypertension management.
Sildenafil Citrate API should be handled according to standard pharmaceutical material safety and industrial hygiene procedures. Appropriate protective measures must be followed during handling and processing of the urology active pharmaceutical ingredient in GMP manufacturing environments.
Use appropriate personal protective equipment (PPE)
Avoid inhalation of powder and contact with skin or eyes
Handle in controlled pharmaceutical manufacturing areas
Follow GMP material handling procedures
Refer to Safety Data Sheet (SDS) for detailed safety guidance
This API is intended exclusively for pharmaceutical manufacturing and formulation use.
Sildenafil Citrate is a phosphodiesterase type-5 (PDE5) inhibitor that prevents the breakdown of cyclic guanosine monophosphate (cGMP) in smooth muscle cells. Elevated cGMP levels promote smooth muscle relaxation and vasodilation in the corpus cavernosum and pulmonary vasculature, enhancing blood flow. This mechanism supports its therapeutic use in erectile dysfunction and pulmonary arterial hypertension.
Handle in approved pharmaceutical manufacturing facilities
Avoid exposure without protective equipment
Prevent dust generation and inhalation
Follow GMP containment procedures
Dispose according to regulatory guidelines
Store in tightly closed containers
Protect from moisture and light
Maintain controlled room temperature
Keep in designated API storage areas
Follow GMP warehouse practices
Sildenafil Citrate API is used in pharmaceutical formulations for the treatment of erectile dysfunction and pulmonary arterial hypertension.
Yes, Chemox Pharma is a WHO-GMP certified Sildenafil Citrate API manufacturer and supplier in India serving global pharmaceutical companies.
The CAS number of Sildenafil Citrate API is 171599-83-0.
Sildenafil Citrate belongs to the phosphodiesterase-5 (PDE5) inhibitor class of urology therapeutic agents used in erectile dysfunction and pulmonary hypertension treatment.
It should be stored in tightly closed containers at controlled room temperature, protected from moisture and light, following pharmaceutical storage guidelines.
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