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FLUCONAZOLE

CPPL / Product / FLUCONAZOLE

FLUCONAZOLE

FLUCONAZOLE
Chemical name: 2-(2,4-Difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl) propan-2-ol, α-(2,4-Difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazol-1-ethanol
Cas number: 86386-73-4
Molecular formula: C13H12F2N6O
Molecular weight: 306.27
Therapeutic uses: Anti – Fungal / Triazoles
Specifications: IP/BP/USP
Appearance: White or almost white crystalline powder
Storage: Keep in dark place, sealed in dry, room temperature <25°C
Therapeutic Class: Intermediates, heterocycles, aromatics, Fine Chemicals

Description:

Fluconazole [Cas No. 86386-73-4] is a triazole antifungal API which is widely used for topical and systemic antifungal therapies. Fluconazole is first generation compound that targets a broad spectrum of fungus by inhibiting 14α-demethylase enzyme, which is a key component for ergosterol synthesis. Leading to the deterioration of fungal cell membrane integrity and stops fungal proliferation.

Fluconazole is widely used as it has high bioavailability, excellent safety, high tolerance level and deep tissue penetration. It is widely used in candidiasis, cryptococcosis, blastomycosis and other infections.

Chemox Pharma is a pharma grade Fluconazole API Manufacturer that meets all global regulatory standards like WHO-GMP, FDA, DCGI. Chemox Pharma also house a well-equipped R&D Centre, focused on process development, quality improvement, and cost optimization—empowering us to meet the evolving needs of the global pharmaceutical industry.

Applications

Sr. No. Description Application
1 Triazole antifungal API Oral antifungal formulations
2 Systemic antifungal drug substance Candidiasis treatment
3 Broad-spectrum antifungal ingredient Fungal infection therapy
4 Antifungal pharmaceutical API Vaginal and systemic infections
5 Anti-infective azole compound Opportunistic fungal infection treatment

Fluconazole is widely used by pharmaceutical manufacturers in oral and injectable antifungal formulations for systemic and mucosal fungal infection management.

Product Specifications

Fluconazole API should be handled according to standard pharmaceutical material safety and industrial hygiene procedures. Appropriate protective measures must be followed during handling and processing of the antifungal active pharmaceutical ingredient in GMP manufacturing environments.

  • Use appropriate personal protective equipment (PPE)

  • Avoid inhalation of powder and contact with skin or eyes

  • Handle in controlled pharmaceutical manufacturing areas

  • Follow GMP material handling procedures

  • Refer to Safety Data Sheet (SDS) for detailed safety guidance

This API is intended exclusively for pharmaceutical manufacturing and formulation use.

Mechanism of Actions

Fluconazole is a triazole antifungal agent that inhibits fungal cytochrome P450–dependent lanosterol 14-α-demethylase, an enzyme required for ergosterol synthesis in fungal cell membranes. Inhibition of ergosterol production disrupts membrane integrity and fungal cell growth, leading to antifungal activity against susceptible organisms such as Candida and Cryptococcus species.

Safety Precautions

  • Handle in approved pharmaceutical manufacturing facilities

  • Avoid exposure without protective equipment

  • Prevent dust generation and inhalation

  • Follow GMP containment procedures

  • Dispose according to regulatory guidelines

Storage

  • Store in tightly closed containers

  • Protect from moisture and light

  • Maintain controlled room temperature

  • Keep in designated API storage areas

  • Follow GMP warehouse practices

FAQs

What is Fluconazole API used for?

Fluconazole API is used in pharmaceutical formulations for the treatment of systemic and mucocutaneous fungal infections such as candidiasis and cryptococcosis.

Is Chemox Pharma a Fluconazole API manufacturer in India?

Yes, Chemox Pharma is a WHO-GMP certified Fluconazole API manufacturer and supplier in India serving global pharmaceutical companies.

What is the CAS number of Fluconazole?

The CAS number of Fluconazole API is 86386-73-4.

What is the therapeutic class of Fluconazole API?

Fluconazole belongs to the triazole antifungal class of anti-infective agents used in fungal infection treatment.

How should Fluconazole API be stored?

It should be stored in tightly closed containers at controlled room temperature, protected from moisture and light, following pharmaceutical storage guidelines.

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