1 in 2 people suffer from a urology disease at some point in their life (source). Overactive bladder (OAB) is one of the most common of these diseases which also takes a toll on your lifestyle and mental health. Therefore, overactive bladder treatments have improved considerably in recent years. One of the most reliable treatments is Mirabegron. In this blog, we will highlight the Mirabegron benefits and its comparison with Solifenacin, a treatment alternative for overactive bladder.
What is Mirabegron in Urology?
Mirabegron is a popular Beta-3 adrenergic agonist used to help patients control frequent urination. Mirabegron relaxes the smooth muscle, resulting in improved muscle control. Therefore, it is widely used for treating an overactive bladder. Furthermore, it is also used in combination treatment for urological conditions such as Overactive Bladder (OAB) and Neurogenic Detrusor Overactivity (NDO).
It is the first licensed Beta-3 adrenoceptor agonist for patients with overactive bladder who require medicines with fewer side effects. To create an effective medicine for OAB, a high-quality Mirabegron API is required. Chemox Pharma can help you customize the pharmacopoeia standards of any API or Intermediate. Contact us to know more.
What are the Mirabegron benefits?
Let’s explore why Mirabegron is a popular treatment for overactive bladder.
Controls overactive bladder
The Beta-3 adrenergic agonist targets the muscles in the bladder, resulting in muscle relaxation and overcoming the symptoms of an overactive bladder, such as urgency and frequency of urination during the day and night. Research has shown significant improvements in 4 weeks of starting Mirabegron treatment.
Increases the bladder’s storage capacity
One of the important Mirabegron benefits is the increased bladder capacity. Due to better muscle control, patients can hold more urine and reduce their bathroom visits, thereby improving the quality of life for patients.
Comparatively lower side effects
Traditionally, antimuscarinic treatment has been used to treat OAB. However, they often cause side effects like dry mouth, constipation, and even vision problems. Mirabegron, on the other hand, has comparatively fewer and milder side effects, such as headache or a slight increase in blood pressure. Therefore, Mirabegron is often used for long-term treatment of an overactive bladder.
Single-dose a day
Half-life of a drug refers to the time required for the drug’s concentration in the bloodstream to be reduced to half. The effect of the medicine reduces as its concentration decreases.
Mirabegron has a half-life of 50 hours. One dose per day is sufficient for the patients. Therefore, it is also a convenient option for long-term treatment of an overactive bladder.
Minimal cognitive impact
The traditional antimuscarinic drugs act on muscarinic receptors to control muscle contractions. However, if they penetrate the blood-brain barrier, they affect the central nervous system, causing cognitive side effects.
However, Beta-3 adrenergic agonists like Mirabegron don’t interfere with the nervous system. Therefore, it has no impact on the patient’s cognitive function. This makes it the most preferred medicine for long-term treatment of urology diseases, such as overactive bladder.
Comparison of Mirabegron and Solifenacin for overactive bladder treatment
Both Solifenacin and Mirabegron are widely used in urology for overactive bladder treatment; they have some significant differences listed in this table.
| Mirabegron | Solifenacin | |
| Action mechanism | It’s a Beta-3 adrenergic agonist that relaxes smooth muscles and controls contractions. | It’s an antimuscarinic drug that blocks acetylcholine from binding to muscarinic receptors, thereby reducing muscle contraction. |
| Half-life | Approximately 50 hours | 33 – 85 hours |
| Common side effects | Headache
Increase in blood pressure Stuffy nose Stomach pain Allergic reaction Trouble passing urine |
Headache
Irregular heartbeats Dry eyes Allergic reaction Cognitive issues Drowsiness |
| Duration for use | Safe for long-term usage | Need to consider the side effects before long-term use |
In many cases, Mirabegron and Solifenacin are used in combination therapy for overactive bladder treatment. However, Mirabegron is often the first-line treatment for OAB.
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Conclusion
Mirabegron benefits patients suffering from an overactive bladder (OAB). It targets the smooth muscles in the bladder to control the contractions. Unlike the traditional antimuscarinic drugs like Solifenacin, Mirabegron doesn’t interact with the neurological system. Therefore, they are often the first-line treatment of OAB. The 50-hour half-life of Mirabegron makes it perfect for long-term treatment. Additionally, it is often used in combination therapy with Solifenacin. Customize the pharmacopoeia standards of Mirabegron API with Chemox Pharma! Contact us to know more.
FAQ
How is Mirabegron used in overactive bladder treatment?
Mirabegron stimulates beta-3 adrenergic receptors in the muscles of the bladder, promoting muscle relaxation and reducing the urgency and frequency of urination. It has a half-life of approximately 50 hours. It also has fewer side effects and no impact on cognitive function. Therefore, one dosage a day is prescribed for long-term treatment.
How long does it take for Mirabegron to show effects on an overactive bladder?
According to surveys and research, it takes around four weeks to see an improvement in bladder activity. It can range between 4 and 8 weeks to see a major impact. The 50-hour half-life makes it perfect for long-term use. The time the drug will start working could be different from one person to another due to personal factors like their age, the status of their bladder, and other medical conditions.
Can I use Mirabegron with Solifenacin for overactive bladder treatment?
Yes, Mirabegron and Solifenacin are used together for better treatment of an overactive bladder. It is vital for patients who don’t see results from one treatment.
Where to find the Mirabegron API manufacturer in India?
Chemox Pharma is one of the most trusted manufacturers of Mirabegron API in India. Our WHO-GMP certified facility enables us to create high-quality, customized APIs from scratch. Improve your drug efficacy with our APIs. Contact us to know more!
