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TIGECYCLINE

CPPL / Product / TIGECYCLINE

TIGECYCLINE

TIGECYCLINE
Chemical name: 9-tert-Butylglycylamidominocycline (4S,4aS,5aR,12aS)-9-(2-(tert-Butyl amino) acetamido)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Cas number: 220620-09-7
Molecular formula: C29H39N5O8
Molecular weight: 585.66
Therapeutic uses: Antibiotic, Antibacterial
Specifications: IP/BP/USP
Appearance: Orange solid
Storage: Keep in dark place, inert atmosphere, store in freezer between 2-8°C
Therapeutic Class: Glycylcycline antibiotic / Antibacterial

Description:

Tigecycline [Cas No. 220620-09-7] is a glycylcycline antibiotic API which is structurally derived from tetracycline class and exhibits high potency, resistance and is very effective against gram positive and gram-negative bacteria. Tigecycline has broad antimicrobial spectrum and has potency to bypass traditional bacterial resistance mechanism. Tigecycline is widely used in treating complicated intra-abdominal infections, skin and soft tissue infections. It is clinical reliable, has broad spectrum efficacy and novel mechanism of action which makes it first choice for serious infections and advanced infectious disease management.

Chemox Pharma offers high-quality pharma grade Tigecycline API Manufacturer with strict quality assurance and supports all global regulatory documents such as WHO-GMP, FDA, DCGI. Chemox Pharma is a reputed manufacturer of high – quality Active Pharmaceutical Ingredients (APIs) and advanced Intermediates with its multipurpose ultramodern state-of-the-art facility at Dahej Industrial area of Gujarat, India. We believe in delivering quality products with competitive prices and delivery on time. The goal of Chemox Pharma is to deliver pharmaceutical solutions that meet the growing needs of the global healthcare industry, ensuring better health globally.

Applications

Sr. No. Description Application
1 Glycylcycline antibiotic API Injectable antibacterial formulations
2 Broad-spectrum antibiotic drug substance Resistant bacterial infection therapy
3 Anti-infective pharmaceutical ingredient Complicated skin infections
4 Advanced tetracycline derivative API Intra-abdominal infection treatment
5 Hospital antibiotic API Severe bacterial infection management

Tigecycline is widely used by pharmaceutical manufacturers in injectable antibiotic formulations for multidrug-resistant bacterial infection treatment.

Product Specifications

Tigecycline API should be handled according to standard pharmaceutical material safety and industrial hygiene procedures. Appropriate protective measures must be followed during handling and processing of the antibiotic active pharmaceutical ingredient in GMP manufacturing environments.

  • Use appropriate personal protective equipment (PPE)

  • Avoid inhalation of powder and contact with skin or eyes

  • Handle in controlled pharmaceutical manufacturing areas

  • Follow GMP material handling procedures

  • Refer to Safety Data Sheet (SDS) for detailed safety guidance

This API is intended exclusively for pharmaceutical manufacturing and formulation use.

Mechanism of Actions

Tigecycline is a glycylcycline antibiotic that binds to the 30S ribosomal subunit of bacteria, inhibiting protein synthesis by blocking the entry of aminoacyl-tRNA into the ribosome. This mechanism prevents bacterial growth and replication. Tigecycline retains activity against many tetracycline-resistant bacteria due to structural modifications that overcome common resistance mechanisms.

Safety Precautions

  • Handle in approved pharmaceutical manufacturing facilities

  • Avoid exposure without protective equipment

  • Prevent dust generation and inhalation

  • Follow GMP containment procedures

  • Dispose according to regulatory guidelines

Storage

  • Store in tightly closed containers

  • Protect from moisture and light

  • Maintain controlled room temperature

  • Keep in designated API storage areas

  • Follow GMP warehouse practices

FAQs

What is Tigecycline API used for?

Tigecycline API is used in pharmaceutical formulations for the treatment of severe and multidrug-resistant bacterial infections, including complicated skin and intra-abdominal infections.

Is Chemox Pharma a Tigecycline API manufacturer in India?

Yes, Chemox Pharma is a WHO-GMP certified Tigecycline API manufacturer in India serving global pharmaceutical companies.

What is the CAS number of Tigecycline?

The CAS number of Tigecycline API is 220620-09-7.

What is the therapeutic class of Tigecycline API?

Tigecycline belongs to the glycylcycline antibiotic class of anti-infective agents used for resistant bacterial infection treatment.

How should Tigecycline API be stored?

It should be stored in tightly closed containers at controlled room temperature, protected from moisture and light, following pharmaceutical storage guidelines.

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