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Rosuvastatin Calcium

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Rosuvastatin Calcium

Rosuvastatin Calcium

Chemical Name: Rosuvastatin Calcium

Other Names: Bis[(E)-7-4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl-3,5-dihydroxyhept-6-enoic acid] calcium salt

CAS Number: 147098-20-2

Molecular Formula: (C22H27FN3O6S)2Ca

Molecular Weight: 1001.14

Therapeutic Uses: Hyperlipidemia, Cardiovascular Risk Reduction, Atherosclerosis

Specifications: IP / EP / USP

Appearance: White to off-white powder

Storage: Store below 25°C in a dry, tightly sealed container. Protect from light and moisture.

Therapeutic Class: Antilipemic Agent | HMG-CoA Reductase Inhibitor | Statin | Lipid-Lowering Drug

Description:

Rosuvastatin Calcium [CAS No: 147098-20-2] is used to manage dyslipidemia and prevent cardiovascular diseases. Rosuvastatin Calcium is widely used to reduce elevated levels of LDL cholesterol, total cholesterol and triglycerides, and moderately increase HDL cholesterol. Rosuvastatin Calcium is a HMG-CoA reductase inhibitor that works by inhibiting enzyme responsible for cholesterol biosynthesis in the liver.

Rosuvastatin Calcium plays vital role in primary and secondary prevention of atherosclerotic cardiovascular events, and is used for both short term and long-term use. Rosuvastatin Calcium has high affinity for hepatic tissues, ensuring targeted efficacy with minimal off-targeted effects.

Chemox Pharma is a leading Rosuvastatin Calcium api Manufacturer [CAS No: 147098-20-2] with strict quality assurance and supports all global regulatory documents such as WHO-GMP, FDA, DCGI. Chemox Pharma is a reputed manufacturer of high – quality Active Pharmaceutical Ingredients (APIs) and advanced Intermediates with its multipurpose ultramodern state-of-the-art facility at Dahej Industrial area of Gujarat, India. Chemox Pharma pride on delivering innovative, reliable, and competitively priced solutions, ensuring timely delivery to meet the needs of the global pharmaceutical industry.

Applications

Sr. No. Description Application
1 Statin antihyperlipidemic API Hypercholesterolemia treatment
2 Lipid-lowering pharmaceutical ingredient Dyslipidemia management
3 Cardiovascular therapeutic API Atherosclerosis prevention
4 Cholesterol synthesis inhibitor API LDL cholesterol reduction
5 Statin drug substance Cardiovascular risk reduction formulations

Rosuvastatin Calcium is widely used by pharmaceutical manufacturers in formulations for cholesterol management and prevention of cardiovascular diseases.

Product Specifications

Rosuvastatin Calcium API should be handled according to standard pharmaceutical material safety and industrial hygiene procedures. Appropriate protective measures must be followed during handling and processing of the active pharmaceutical ingredient in GMP manufacturing environments.

  • Use appropriate personal protective equipment (PPE)

  • Avoid inhalation of powder and contact with skin or eyes

  • Handle in controlled pharmaceutical manufacturing areas

  • Follow GMP material handling procedures

  • Refer to Safety Data Sheet (SDS) for detailed safety guidance

This API is intended exclusively for pharmaceutical manufacturing and formulation use.

Mechanism of Actions

Rosuvastatin Calcium is a statin class antihyperlipidemic agent that selectively inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol biosynthesis. By reducing cholesterol production and increasing hepatic LDL receptor expression, it enhances clearance of circulating LDL cholesterol and lowers total plasma lipid levels. This mechanism supports its therapeutic role in hyperlipidemia and cardiovascular disease prevention.

Safety Precautions

  • Handle in approved pharmaceutical manufacturing facilities

  • Avoid exposure without protective equipment

  • Prevent dust generation and inhalation

  • Follow GMP containment procedures

  • Dispose according to regulatory guidelines

Storage

  • Store in tightly closed containers

  • Protect from moisture and light

  • Maintain controlled room temperature

  • Keep in designated API storage areas

  • Follow GMP warehouse practices

FAQs

What is Rosuvastatin Calcium API used for?

Rosuvastatin Calcium API is used in pharmaceutical formulations for lowering cholesterol levels and reducing the risk of cardiovascular diseases such as atherosclerosis and heart attack.

Is Chemox Pharma a Rosuvastatin Calcium API manufacturer in India?

Yes, Chemox Pharma is a WHO-GMP certified Rosuvastatin Calcium API manufacturer in India serving global pharmaceutical companies.

What is the CAS number of Rosuvastatin Calcium?

The CAS number of Rosuvastatin Calcium API is 147098-20-2.

What is the therapeutic class of Rosuvastatin API?

Rosuvastatin belongs to the statin class of antihyperlipidemic agents used for cholesterol reduction and cardiovascular risk management.

How should Rosuvastatin Calcium API be stored?

It should be stored in tightly closed containers at controlled room temperature, protected from moisture and light, following pharmaceutical storage guidelines.

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