NITROFURANTOIN

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NITROFURANTOIN

NITROFURANTOIN
Chemical name: 1-[(5-Nitrofurfurylidene) amino]hydantoin, 1-[[(5-Nitro-2-furanyl)methylene]amino]-2,4-imidazolidinedione
Cas number: 67-20-9
Molecular formula: C8H6N4O5
Molecular weight: 238.16
Therapeutic uses: Antibiotic, Antibacterial
Specifications: IP/BP/USP
Appearance: Pale Yellow Crystalline Powder
Storage: Room Temperature (Recommended in a cool and dark place, <25°C)
Therapeutic Class: Nitrofuran derivative

Description:

Nitrofurantoin [Cas No. 67-20-9] is an antibacterial API which is effectively used for the treatment and prevention of urinary tract infections [UTIs]. Common market brand name for Nitrofurantoin is Macrobid, which breaks bacterial enzyme systems and DNA, resulting in inhibiting bacterial growth. Nitrofurantoin has good safety profile due to which it can be administered during pregnancy and has low level of resistant development. It is widely used to treat both acute as well as long term prophylaxis.

Chemox Pharma provides high-quality pharma grade Nitrofurantoin API that complies with all global regulatory standards such as like WHO-GMP, FDA, DCGI. Our API products are trusted by pharmaceutical industries, which reflects our global footprints and reputation. Chemox Pharma pride on delivering innovative, reliable, and competitively priced solutions, ensuring timely delivery to meet the needs of the global pharmaceutical industry.

Applications

Sr. No. Description Application
1 Nitrofuran antibacterial API Urinary tract infection formulations
2 Urology anti-infective drug substance UTI treatment capsules/tablets
3 Broad-spectrum urinary antibiotic Bacterial cystitis therapy
4 Antibacterial pharmaceutical ingredient Lower UTI management
5 Urogenital anti-infective API Recurrent UTI prevention drugs

Nitrofurantoin is widely used by pharmaceutical manufacturers in oral antibacterial formulations for urinary tract infection management.

Product Specifications

Nitrofurantoin API should be handled according to standard pharmaceutical material safety and industrial hygiene procedures. Appropriate protective measures must be followed during handling and processing of the antibacterial active pharmaceutical ingredient in GMP manufacturing environments.

  • Use appropriate personal protective equipment (PPE)

  • Avoid inhalation of powder and contact with skin or eyes

  • Handle in controlled pharmaceutical manufacturing areas

  • Follow GMP material handling procedures

  • Refer to Safety Data Sheet (SDS) for detailed safety guidance

This API is intended exclusively for pharmaceutical manufacturing and formulation use.

Mechanism of Actions

Nitrofurantoin is a nitrofuran antibacterial agent that is reduced by bacterial flavoproteins to reactive intermediates. These intermediates damage bacterial DNA, ribosomal proteins, and metabolic enzymes, leading to inhibition of bacterial growth and cell death. Nitrofurantoin achieves high urinary concentrations, making it effective for urinary tract infections.

Safety Precautions

  • Handle in approved pharmaceutical manufacturing facilities

  • Avoid exposure without protective equipment

  • Prevent dust generation and inhalation

  • Follow GMP containment procedures

  • Dispose according to regulatory guidelines

Storage

  • Store in tightly closed containers

  • Protect from moisture and light

  • Maintain controlled room temperature

  • Keep in designated API storage areas

  • Follow GMP warehouse practices

FAQs

What is Nitrofurantoin API used for?

Nitrofurantoin API is used in pharmaceutical formulations for the treatment and prevention of urinary tract infections (UTIs).

Is Chemox Pharma a Nitrofurantoin API manufacturer in India?

Yes, Chemox Pharma is a WHO-GMP certified Nitrofurantoin API manufacturer and supplier in India serving global pharmaceutical companies.

What is the CAS number of Nitrofurantoin?

The CAS number of Nitrofurantoin API is 67-20-9.

What is the therapeutic class of Nitrofurantoin API?

Nitrofurantoin belongs to the nitrofuran antibacterial class of anti-infective agents used in urinary tract infection treatment.

How should Nitrofurantoin API be stored?

It should be stored in tightly closed containers at controlled room temperature, protected from moisture and light, following pharmaceutical storage guidelines.

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