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Methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate

CPPL / Product / Methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate

Methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate

fexofenadine intermediate

Methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate is a chlorinated aromatic ketone ester used as a pharmaceutical intermediate in the synthesis of fexofenadine hydrochloride. It provides a functionalized aromatic structure for subsequent chemical transformations during pharmaceutical manufacturing.

Description:

Methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate is a chlorinated aromatic ketone ester used as a pharmaceutical intermediate in the synthesis of fexofenadine hydrochloride. It provides a functionalized aromatic structure for subsequent chemical transformations during pharmaceutical manufacturing.

Chemox Pharma serves pharmaceutical manufacturers and sourcing partners seeking pharmaceutical intermediates for downstream API production, supported by appropriate quality documentation and product-specific specifications.

Applications

  • Fexofenadine hydrochloride synthesis: Used as a chemical intermediate in a synthetic route associated with fexofenadine production.

  • Pharmaceutical manufacturing: Supports downstream chemical transformations involved in API synthesis.

  • Process development: May be relevant to synthetic-route development and process optimization.

  • Quality control: Can be assessed for identity, purity, and process-related impurities according to the applicable analytical specification.

Product Specifications

Handle this compound using appropriate industrial chemical controls. Its complete hazard classification should be determined from the current supplier SDS rather than inferred from its chemical structure.

  • Wear appropriate gloves, protective clothing, and safety goggles.

  • Avoid inhalation, ingestion, and direct skin or eye contact.

  • Use adequate ventilation during handling and processing.

  • Keep containers properly closed and clearly labelled.

  • Prevent environmental release and dispose of chemical waste according to applicable requirements.

  • Follow the SDS for first aid, spill response, fire response, transportation, and storage.

Mechanism of Actions

This compound is a pharmaceutical intermediate, not the active antihistamine itself. Its role is to provide a chemical building block for downstream synthesis.
Fexofenadine hydrochloride, the final API, acts as a selective peripheral histamine H₁-receptor antagonist. It blocks histamine-mediated activity at peripheral H₁ receptors and helps relieve allergy symptoms, including sneezing, runny nose, itchy eyes, and itching associated with urticaria.

FAQs

1. What is Methyl 2-[4-(4-chlorobutanoyl)phenyl]-2-methylpropanoate used for?

It is used as a pharmaceutical intermediate associated with the synthesis of fexofenadine hydrochloride.

2. What is its CAS number?

Its CAS number is 154477-54-0.

3. What is its molecular formula?

Its molecular formula is C₁₅H₁₉ClO₃.

4. What is its molecular weight?

Its molecular weight is approximately 282.76 g/mol.

5. Is this compound the same as fexofenadine hydrochloride?

No. It is a chemical intermediate used during synthesis. Fexofenadine hydrochloride is the final active pharmaceutical ingredient.

6. Which documents should be requested before purchase?

Request the current product specification, batch-specific COA, SDS, and applicable quality documentation. Confirm assay, impurity profile, and acceptance criteria before purchase.

7. Is bulk supply available for pharmaceutical manufacturing?

Available quantities, packaging, lead times, and supply conditions should be confirmed directly with Chemox Pharma.

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