FENOFIBRATE

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FENOFIBRATE

Chemical name: Isopropyl 2-(4-(4-chlorobenzoyl) phenoxy)-2-methylpropanoate, Procetofen, Lipofene, 2-[4-(4-Chlorobenzoyl) phenoxy]-2-methyl-propanoic acid 1-methylethyl ester
Cas number: 49562-28-9
Molecular formula: C20H21ClO4
Molecular weight: 360.83
Therapeutic uses: Anti-Cholesterol
Specifications: IP/BP/USP
Appearance: White to off-white crystalline powder
Storage: Room temperature <25°C
Therapeutic Class: Lipid-lowering agent, heart disease prevention

Description:

Fenofibrate is also known as lipid modifying agent widely used for the treatment of hyperlipidemia and hypertriglyceridemia and promotes cardiovascular protection through multiple metabolic pathways. Fenofibrate activates peroxisome proliferator activated receptor alpha [PPARα] which is nuclear receptor that regulates lipid metabolism. Fenofibrate increases overall cardiovascular health and decreases fibrinogen, C-reactive protein as well as uric acid levels.

Fenofibrate has broad efficacy and well tolerance level which shows targeted action resulting in low triglyceride levels. It provides long term lipid management and therefore is widely used in oral solid dosage forms such as tablets and capsules.

Chemox Pharma supplies pharma grade Fenofibrate API which helps in development of innovative formulations for effective cardiovascular wellness and good lipid control that results in empowering the fight against dyslipidaemia and overall metabolic and vascular health. Chemox Pharma offers consistent high-quality API and follow WHO-GMP regulated standards.

Applications

Sr. No. Description Application
1 Lipid-lowering API Dyslipidemia formulations
2 Fibric acid derivative drug substance Hypertriglyceridemia therapy
3 Cardiovascular therapeutic ingredient Cholesterol reduction drugs
4 PPAR-α agonist pharmaceutical API Mixed dyslipidemia treatment
5 Antihyperlipidemic API Atherosclerosis risk reduction

Fenofibrate is widely used by pharmaceutical manufacturers in oral lipid-lowering formulations for cholesterol and triglyceride management.

Product Specifications

Fenofibrate API should be handled according to standard pharmaceutical material safety and industrial hygiene procedures. Appropriate protective measures must be followed during handling and processing of the cardiovascular active pharmaceutical ingredient in GMP manufacturing environments.

  • Use appropriate personal protective equipment (PPE)

  • Avoid inhalation of powder and contact with skin or eyes

  • Handle in controlled pharmaceutical manufacturing areas

  • Follow GMP material handling procedures

  • Refer to Safety Data Sheet (SDS) for detailed safety guidance

This API is intended exclusively for pharmaceutical manufacturing and formulation use.

Mechanism of Actions

Fenofibrate is a fibric acid derivative that activates peroxisome proliferator-activated receptor alpha (PPAR-α). Activation of PPAR-α enhances lipoprotein lipase activity, increases fatty acid oxidation, and reduces hepatic triglyceride production. This leads to decreased triglycerides, reduced LDL cholesterol, and increased HDL cholesterol, improving lipid profiles in dyslipidemia patients.

Safety Precautions

  • Handle in approved pharmaceutical manufacturing facilities

  • Avoid exposure without protective equipment

  • Prevent dust generation and inhalation

  • Follow GMP containment procedures

  • Dispose according to regulatory guidelines

Storage

  • Store in tightly closed containers

  • Protect from moisture and light

  • Maintain controlled room temperature

  • Keep in designated API storage areas

  • Follow GMP warehouse practices

FAQs

What is Fenofibrate API used for?

Fenofibrate API is used in pharmaceutical formulations for the treatment of dyslipidemia and hypertriglyceridemia to reduce cholesterol and triglyceride levels.

Is Chemox Pharma a Fenofibrate API manufacturer in India?

Yes, Chemox Pharma is a WHO-GMP certified Fenofibrate API manufacturer and supplier in India serving global pharmaceutical companies.

What is the CAS number of Fenofibrate?

The CAS number of Fenofibrate API is 49562-28-9.

What is the therapeutic class of Fenofibrate API?

Fenofibrate belongs to the fibric acid derivative (PPAR-α agonist) class of lipid-lowering agents used in cholesterol and triglyceride management.

How should Fenofibrate API be stored?

It should be stored in tightly closed containers at controlled room temperature, protected from moisture and light, following pharmaceutical storage guidelines.

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