EMTRICITABINE

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EMTRICITABINE

EMTRICITABINE
Chemical name: 4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone)
Cas number: 143491-57-0
Molecular formula: C8H10FN3O3S
Molecular weight: 247.24
Therapeutic uses: Nucleoside transcriptase inhibitor
Specifications: IP/BP/USP
Appearance: White to Off-White Solid
Storage: Room Temperature (Recommended in a cool and dark place, <15°C)
Therapeutic Class: Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Description:

Emtricitabine [Cas No. 143491-57-0] is a nucleoside reverse transcriptase inhibitor [NRTI] API which is mostly used in treatment of antiviral therapies. Emtricitabine is also known as cytidine analogue and treats HIV-1 infections by inhibiting reverse transcriptase enzyme, resulting in blockage of viral replication and reduces viral load in patients. Emtricitabine API has high efficacy against HIV and hepatitis B virus [HBV] and provides high oral availability and has long shelf life.

Chemox Pharma is a trusted supplier of Emtricitabine with strict quality assurance and supports all global regulatory documents such as WHO-GMP, FDA, DCGI. Chemox Pharma is a reputed manufacturer of high – quality Active Pharmaceutical Ingredients (APIs) and advanced Intermediates with its multipurpose ultramodern state-of-the-art facility at Dahej Industrial area of Gujarat, India. Chemox Pharma pride on delivering innovative, reliable, and competitively priced solutions, ensuring timely delivery to meet the needs of the global pharmaceutical industry.

Applications

Sr. No. Description Application
1 Antiretroviral API HIV treatment formulations
2 NRTI drug substance Combination antiretroviral therapy
3 Antiviral therapeutic ingredient HIV-1 infection management
4 Reverse transcriptase inhibitor API HAART formulations
5 Nucleoside analogue antiviral HIV suppression therapy

Emtricitabine is widely used by pharmaceutical manufacturers in antiretroviral formulations for HIV treatment and prevention therapies.

Product Specifications

Emtricitabine API should be handled according to standard pharmaceutical material safety and industrial hygiene procedures. Appropriate protective measures must be followed during handling and processing of the antiviral active pharmaceutical ingredient in GMP manufacturing environments.

  • Use appropriate personal protective equipment (PPE)

  • Avoid inhalation of powder and contact with skin or eyes

  • Handle in controlled pharmaceutical manufacturing areas

  • Follow GMP material handling procedures

  • Refer to Safety Data Sheet (SDS) for detailed safety guidance

This API is intended exclusively for pharmaceutical manufacturing and formulation use.

Mechanism of Actions

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) that is phosphorylated intracellularly to its active triphosphate form. It competitively inhibits HIV reverse transcriptase and incorporates into viral DNA, causing chain termination during viral replication. This mechanism suppresses HIV replication and reduces viral load in infected patients.

Safety Precautions

  • Handle in approved pharmaceutical manufacturing facilities

  • Avoid exposure without protective equipment

  • Prevent dust generation and inhalation

  • Follow GMP containment procedures

  • Dispose according to regulatory guidelines

Storage

  • Store in tightly closed containers

  • Protect from moisture and light

  • Maintain controlled room temperature

  • Keep in designated API storage areas

  • Follow GMP warehouse practices

FAQs

What is Emtricitabine API used for?

Emtricitabine API is used in pharmaceutical formulations for the treatment and prevention of HIV infection as part of antiretroviral therapy.

Is Chemox Pharma an Emtricitabine API manufacturer in India?

Yes, Chemox Pharma is a WHO-GMP certified Emtricitabine API manufacturer and supplier in India serving global pharmaceutical companies.

What is the CAS number of Emtricitabine?

The CAS number of Emtricitabine API is 143491-57-0.

What is the therapeutic class of Emtricitabine API?

Emtricitabine belongs to the nucleoside reverse transcriptase inhibitor (NRTI) class of antiviral agents used in HIV treatment.

How should Emtricitabine API be stored?

It should be stored in tightly closed containers at controlled room temperature, protected from moisture and light, following pharmaceutical storage guidelines.

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